|
|
This is only a preview of the paper
Click here to register and get the full text.
Existing members click here to login
|
|
|
Cancer results from gene mutations that affect the production, function or turnover of signal transduction proteins that control cell proliferation and death. ... The most prominent cause; depending on ones viewpoint, you can look at skin cancer as being principally a genetic determined disorder or, alternatively, an environmental disorder. Ultraviolet radiation is the major environmental hazard but can only exert its effects on a susceptible genotype, namely that leading to a relative reduction in pigmentation (McElwee, 2003). Evidence from a number of different directions points to genetic susceptibility to skin cancer: DNA repair deficiency, such as in patients with Xeroderma pigmentosa; rare familial cancer syndromes such as Gorlins syndrome; and with the greatest attributable risk, relative reduction in pigmentation such as the various forms of albinism (Benson, 2001).
Pigmentation is genetically complex. ... Development of appropriate inter-follicular pigmentation in man is photoprotective against many, if not all of the harmful effects of ultraviolet radiation.
Approximate Word count = 666
Approximate Pages = 2.7
(250 words per page double spaced)
|
|
|
|
|
|