Ayyur
...nthion, chlorpyrifos cause OPIDN in humans. Carbamates (ex. Aldicarb, methomyl) are reversible inhibitors of nervous tissues AchE unlike OPs. These are rapidely biotransformed in vivo. Today 200 different OPs and around 25 carbamates insecticides are in use. These were derived from “nerve gases” hence they are very toxic. However today we are four generations of development away from those highly toxic chemicals. As the name implies both inhibit acetylcholinesterase (AchE), which leads to accumulation of free, unbound acetylcholine leading to continual stimulation of electrical activity. Clinical condition: Three types of signs exist: Stimulation of muscarinic receptors of the parasympathetic autonomic nervous system leads to increased secretions, bronchoconstriction, GI cramps, diarrhea, bradycardia. Parasympathetic divisions of the autonomic nervous system as well as the junctions between nerves and muscles leads to tachycardia, hypertension, tremors, muscle weakness, muscle fasciculation. Effects on CNS are restlessness, emotional liability, ataxia, lethargy, convulsion, cyanosis, and coma. A major manifestation of exposure to organophosphorus ester insecticides is the OPIDN (organophosphate-induced delayed neurotoxicity). A number of OPs including methoate, parathion, trichloronate, trichlorfon, fenthion, chlorpyrifos cause OPIDN in humans. Carbamates (ex. Aldicarb, methomyl) are reversible inhibitors of nervous tissues AchE unlike OPs. These are rapidely biotransformed in vivo. Today 200 different OPs and around 25 carbamates insecticides are in use. These were derived from “nerve gases” hence they are very toxic. However today we are four generations of development away from those highly toxic chemicals. As the name implies both inhibit acetylcholinesterase (AchE), which leads to accumulation of free, unbound acetylcholine leading to continual stimulation of electrical activity. Clinical condition: Three types of signs exist: Stimulation of muscarinic receptors of the parasympathetic autonomic nervous system leads to increased secretions, bronchoconstriction, GI cramps, diarrhea, bradycardia. Parasympathetic divisions of the autonomic nervous system as well as the junctions between nerves and muscles leads to tachycardia, hypertension, tremors, muscle weakness, muscle fasciculation. Effects on CNS are restlessness, emotional liability, ataxia, lethargy, convulsion, cyanosis, and coma. A major manifestation of exposure to organophosphorus ester insecticides is the OPIDN (organophosphate-induced delayed neurotoxicity). A number of OPs including methoate, parathion, trichloronate, trichlorfon, fenthion, chlorpyrifos cause OPIDN in humans. Carbamates (ex. Aldicarb, methomyl) are reversible inhibitors of nervous tissues AchE unlike OPs. These are rapidely biotransformed in vivo. Today 200 different OPs and around 25 carbamates insecticides are in use. These were derived from “nerve gases” hence they are very toxic. However today we are four generations of development away from those highly toxic chemicals. As the name implies both inhibit acetylcholinesterase (AchE), which leads to accumulation of free, unbound acetylcholine leading to continual stimulation of electrical activity. Clinical condition: Three types of signs exist: Stimulation of muscarinic receptors of the parasympathetic autonomic nervous system leads to increased secretions, bronchoconstriction, GI cramps, diarrhea, bradycardia. Parasympathetic divisions of the autonomic nervous system as well as the junctions between nerves and muscles leads to tachycardia, hypertension, tremors, muscle weakness, muscle fasciculation. Effects on CNS are restlessness, emotional liability, ataxia, lethargy, convulsion, cyanosis, and coma. A major manifestation of exposure to organophosphorus ester insecticides is the OPIDN (organophosphate-induced delayed neurotoxicity). A number o...