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Although the synthesis occurs through similar intermediates with oxidation, it has different electron carriers, carboxyl group activation, stereochemistry and cellular location. Fatty Acid oxidation happens by the oxidative removal of the two carbon Acetyl-CoA. ... Fatty acid synthesis occurs in the cytosol in mammals and in chloroplasts in plants which segregates the synthetic processes from degredative reactions which take place in the mitochondrial matrix. ... Another example of the difference between the synthesis and the degradation is that malonyl-CoA, a three carbon-intermediate in the synthesis is not present in the degradation. Malonyl-CoA is an activated intermediate in the synthesis and is a major distinction with the degradation. ... Acetyl CoA is generated in the mitochondrial matrix and brought to the cytosol for fatty acid synthesis using a shuttle system involving citrate. ... Bicarbonate is an absolute requirement in fatty acid synthesis because of this, however, it is not used in the degradation. ... With each passage through the cycle, the fatty acid is extended with two carbons, similar to that of the degradation of fatty acids.
Approximate Word count = 862
Approximate Pages = 3.4
(250 words per page double spaced)
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