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coon dog and a tick, an oak tree with moss on the north side, a termite and its internal bacteria, and a shark with tiny fish that eat the extra meat chunks in between the teeth all have one thing in common: symbiosis. Defined as the interdependence of organisms, symbiosis is the basis of the relationship between George and Lennie in “Of Mice and Men” by John Steinbeck. One type of symbiosis helps both parties while another type involves one organism being hurt by the exchange. The dog is hurt by the tick while the termites and the bacteria benefit from each other’s presence. These types of symbiosis can occur in humans and are evident in “Of Mice and Men.” Both types of symbiosis exist between George and Lennie in the novel. The physical symbiosis of George and Lennie is beneficial to Lennie but detrimental to George.