use of protonix
... Exclusion criteria included use of histamine receptor antagonists within 2 weeks, or other PPIs within 1 month before participating in the study. ... This compelling study provides convincing evidence for the effectiveness and potential benefit of pantoprazole use. The information is particularly useful because the study design and methods are clearly delineated, and the use of randomized patient groups with a placebo control eliminate several potential confounding variables. The standardized criteria for disease severity are clearly established, and the use of a scale based on endoscopic evidence strengthens the conclusions drawn. ... This was only a minor part of the study, however, and the use of diary cards to be filled out by patients themselves helped eliminate any possible influence that investigators could have directly had. ... Hence, while able to draw conclusions regarding the use of i. ... pantoprazole in maintenance of already-established acid suppression, one cannot compare it to use of p. ... As a review of the research literature indicates, the abundance of well-designed randomized studies has not only broadened our understanding of its properties, but it has also provided relevant guidelines for its use in clinical practice.