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The first article discusses disseminated intravascular coagulation (DIC). This is a "hematological phenomenon that occurs when clotting cascades and fibrinolytic systems are both over-activated.” The clots go throughout the body instead of localizing to a tissue injury. This can cause severe problems because all the clots get used up and there won't be any more clots for tissue injuries. The management is to treat the underlying cause of DIC. The patient must maintain adequate fluid, cardiac output, blood pressure, renal perfusion, tissue oxygenation, and caloric intake. They can use anticoagulants if it can't be removed but this is controversial. The article also mentions fibrinolytic inhibitors and epsilon amino caproic and tranexamic acid. Replacement of platelets and clotting factors can be done by administering fresh frozen plasma, packed red blood cells, and platelets that may counteract deficiencies. The main concern is to make sure that the organ function is maintained because of the large amounts of blood loss.
Approximate Word count = 568
Approximate Pages = 2.3
(250 words per page double spaced)
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